Daflon For Heavy, Painful legs and Varicose Veins

Recommended, non prescription brand for treating chronic venous insufficiency symptoms ¹

How does Daflon work?

Venoactive treatments, like Daflon, are designed to help improve our leg vein health by strengthening the tone of our veins, which continue to weaken as chronic venous insufficiency progresses.

Daflon has a dual mechanism of action; its venous anti-inflammatory action venoprotective reduces pain and swelling; it also protects the capillaries or tiny blood vessels to improve microcirculation and venous tone for better vein health and relief of symptoms such as leg pain, and swelling. ²

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Tackle leg pain from the inside

Daflon is a clinically proven, effective and convenient oral treatment derived from immature oranges and specially formulated for maximum absorption. ²

This improved absorption means Daflon can get to the root of the problem and effectively treat veins from the inside, improving the tone of veins, potentially protecting against disease progression and providing relief from heavy, painful leg symptoms. ²

Improved Absorption

Specially formulated from small, immature oranges using a micronisation process, Daflon is absorbed twice as well as non micronised alternatives for effective relief from painful symptoms. ³

Demonstrated effect of Daflon Over 8 weeks

4 weeks ⁴

8 weeks ⁴

Leg pain

50%

63%

Sensation of heaviness

50%

65%

Sensation of swelling

50%

63%

Relieves Symptoms

Recommended, non prescription brand for treating chronic venous insufficiency symptoms. ¹

Clinical Studies have shown that Daflon can reduce leg pain and the sensations of heaviness and swelling by up to 50% after only one month of use. These figures were even higher after two months of treatment.

To benefit from your Daflon treatment, you should take your medication as recommended. Be sure to monitor your condition closely and speak with a health care professional if you have any concerns.

Why you should treat early

Daflon is a venoactive drug treatment which, thanks to its venous anti-inflammatory and venoprotective actions, can potentially prevent the development and progression of chronic venous insufficiency. ² This progressive condition requires treatment from the earliest stages of disease. Lifestyle changes, compression stockings and using a venoactive drug treatment that tackles the root cause of the problem can help alleviate painful symptoms. By treating early with Daflon you can help relieve symptoms and prevent them getting worse. ⁵

Daflon. Naturally sourced, scientifically prepared.

The active ingredient in Daflon is a micronized purified flavonoid fraction (MPFF)6 containing 90% diosmin and 10% other flavonoids expressed as hesperidin.

Daflon’s flavonoids are extracted from immature oranges that are rich in these naturally occurring plant chemicals. The compounds undergo a process of purification and refinement where the particles are made to collide with each other at high speeds (micronization), reducing them to tiny particles, less than 2 μm in size (micronized). These smaller particles are absorbed twice as easily by the body and are a key ingredient of Daflon’s success as a treatment for improving vein health and tone in Chronic Venous Insufficiency and Hemorrhoids. ⁶

Safety Information:

Daflon 500mg Safety Information

Daflon 500: Micronized, purified flavonoid fraction 500 mg: 450 mg diosmin; 50 mg flavonoids expressed as hesperidine.

INDICATIONS*

Treatment of the symptoms of chronic venous disease of the lower limbs, either organic or functional: feeling of heavy legs, pain, night cramps. Treatment of acute hemorrhoidal episodes.

DOSAGE AND ADMINISTRATION*

In venous disease: 1000mg daily.In acute hemorrhoidal attacks: the dosage can be increased up to 3000mg daily.

CONTRAINDICATIONS*

Hypersensitivity to the active substance or to any of the excipients.

WARNINGS*

The administration of this product for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.

Excipients: sodium-free.

INTERACTION(S)*

FERTILITY* PREGNANCY / LACTATION* - Treatment should be avoided.

DRIVE & USE MACHINES*

UNDESIRABLE EFFECTS*

Common: diarrhoea, dyspepsia, nausea, vomiting. Rare: dizziness, headache, malaise, rash, pruritus, urticaria. Uncommon: colitis. Frequency not known: abdominal pain, isolated face, lip, eyelid oedema. Exceptionally Quincke's oedema.

OVERDOSE PROPERTIES*

Vascular protector and venotonic.

[Tradename] acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.

PRESENTATION*

LES LABORATOIRES SERVIER, 50 rue Carnot, 92284 Suresnes cedex France. www.servier.com *

For complete information, please refer to the Summary of Product Characteristics for your country.

References:

IQVIA Daflon sales data MAT Q2 2021
Adapted from Nicolaides A, Kakkos S, Baekgaard N, et al. Management of chronic venous disorders of the lower limbs. Guidelines according to scientific evidence. Part I. Int Angiol. 2018;37(3):181-254.1
Garner RC, Garner JV, Gregory S, Whattam M, Calam A, Leong D. Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting. J Pharm Sci. 2002;91:32-40.
Gilly R, Pillion G, Frileux C. Evaluation of a new venoactive micronized flavonoid fraction (S 5682) in symptomatic disturbances of the venolymphatic circulation of the lower limb: a double-blind, placebo-controlled study. Phlebology. 1994;9:67-70.
Pascarella L, Lulic D, Penn AH, et al. Mechanisms in experimental venous valve failure and their modification by Daflon 500 mg. Eur J Vasc Endovasc Surg. 2008;35(1):102-110.
Summary of Product Characteristics Daflon